diff --git a/src/hotspot/cpu/s390/c2_globals_s390.hpp b/src/hotspot/cpu/s390/c2_globals_s390.hpp
index 431a36cda07..125b317588d 100644
--- a/src/hotspot/cpu/s390/c2_globals_s390.hpp
+++ b/src/hotspot/cpu/s390/c2_globals_s390.hpp
@@ -1,5 +1,5 @@
 /*
- * Copyright (c) 2016, 2025, Oracle and/or its affiliates. All rights reserved.
+ * Copyright (c) 2016, 2026, Oracle and/or its affiliates. All rights reserved.
  * Copyright (c) 2016, 2018 SAP SE. All rights reserved.
  * DO NOT ALTER OR REMOVE COPYRIGHT NOTICES OR THIS FILE HEADER.
  *
@@ -44,7 +44,7 @@ define_pd_global(intx, CompileThreshold,             10000);
 
 define_pd_global(intx, OnStackReplacePercentage,     140);
 define_pd_global(intx, ConditionalMoveLimit,         4);
-define_pd_global(intx, FreqInlineSize,               175);
+define_pd_global(intx, FreqInlineSize,               325);
 define_pd_global(intx, InteriorEntryAlignment,       4);
 define_pd_global(size_t, NewSizeThreadIncrease,      ScaleForWordSize(4*K));
 define_pd_global(intx, RegisterCostAreaRatio,        12000);
diff --git a/src/hotspot/share/compiler/compilerDefinitions.cpp b/src/hotspot/share/compiler/compilerDefinitions.cpp
index 75d84bedcc6..9bd6e893bcd 100644
--- a/src/hotspot/share/compiler/compilerDefinitions.cpp
+++ b/src/hotspot/share/compiler/compilerDefinitions.cpp
@@ -404,14 +404,12 @@ void CompilerConfig::set_compilation_policy_flags() {
 #endif
 
   if (CompilerConfig::is_tiered() && CompilerConfig::is_c2_enabled()) {
-#ifdef COMPILER2
-    // Some inlining tuning
-#if defined(X86) || defined(AARCH64) || defined(RISCV64) || defined(PPC64)
+#if defined(COMPILER2) && defined(_LP64)
+    // LP64 specific inlining tuning for C2
     if (FLAG_IS_DEFAULT(InlineSmallCode)) {
       FLAG_SET_DEFAULT(InlineSmallCode, 2500);
     }
 #endif
-#endif // COMPILER2
   }
 
 }